GJG057 - CAS 2761767-18-2

GJG057 is a highly efficient and selective Leukotriene C4 synthase (LTC4S) inhibitor with an IC50 of 44 nM in human whole blood LTC4 release assays and oral activity. It demonstrates anti-inflammatory efficacy in a mouse asthma exacerbation model and can be used for the treatment of allergic inflammation.

Glutathione Peroxidase, GST

Oxidation-Reduction, Metabolism

2761747

0.998

C21H21F5N4O2

456.41

O=C1N(C2=CC=C(F)C(F)=C2)C3(CCN(C=4N=CN=C(OCC(F)(F)F)C4)CC3)CCC1

-20°C

Ice Packs

Small Compound