GlcNAc-MurNAc - CAS 4500-70-3

GlcNAc-MurNAc is a disaccharide and mild TLR4 agonist with a Kd of 383 μM for mouse TLR4. It directly binds to TLR4, activating the downstream NF-κB and IRF pathways. Additionally, GlcNAc-MurNAc ameliorates dextran sulfate sodium salt (DSS) -induced colitis in mice through a TLR4-dependent mechanism, making it useful for inflammatory bowel disease research.

Interleukin, TLR, NF-κB, Caspase, TNF

NF-κB, Proteases/Proteasome, Immunology/Inflammation, Apoptosis

4427

C19H32N2O13

496.46

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-20°C

Ice Packs

Small Compound