Gliotoxin - CAS 67-99-2

Gliotoxin, a Wnt signaling pathway inhibitor, induces growth inhibition and apoptosis in multiple colorectal cancer cell lines with mutations of the Wnt signaling pathway. Gliotoxin is a mycotoxin produced by several moulds such as Aspergillus fumigatus. Gliotoxin activates PKA and increases intracellular cAMP concentration and inhibits inducible NF-κB activity by preventing IκB degradation, which consequently induces host-cell apoptosis.

Wnt/beta-catenin, Antibacterial, Antibiotic, Antifection, Antifungal, COX, NF-κB, Apoptosis, PKA

Stem Cells, Microbiology/Virology, Immunology/Inflammation, NF-κB, Neuroscience, Apoptosis, Tyrosine Kinase/Adaptors, Cytoskeletal Signaling

-34

C13H14N2O4S2

326.39

CN1C(=O)[C@]23CC4=CC=C[C@H](O)[C@H]4N2C(=O)[C@@]1(CO)SS3

-20°C

Ice Packs

Natural Product