GLPG3312 - CAS 2340388-72-7

GLPG3312 is a selective and potent pan-SIK inhibitor with the advantage of oral activity, with IC50=0.6-2.0 nM for SIK1, SIK2 and SIK3, and exhibits anti-inflammatory and immunomodulatory activity in both human primary myeloid cells and mouse models.

Bcr-Abl, TGF-beta/Smad, RIP kinase, Src, SIK, LIM Kinase, Discoidin Domain Receptor (DDR), MAPK

Apoptosis, PI3K/Akt/mTOR signaling, NF-κB, Cell Cycle/Checkpoint, Angiogenesis, Stem Cells, MAPK, Cytoskeletal Signaling, Tyrosine Kinase/Adaptors

2340388-72-7

0.9853

C23H21F2N5O3

453.44

O=C(NC1CC1)C2=C(OC)C=C(C=C2OC(F)F)N3C=NC=4C=C(C=CC43)C=5C=NN(C5)C

-20°C

Ice Packs

Small Compound