β-Glu-PAB (CH2NH2) -Exatecan - CAS 3025108-11-3

β-Glu-PAB (CH2NH2) -Exatecan (Compound 9a) is an inhibitor of topoisomerase I. It binds to the topoisomerase I-DNA complex, preventing the re-ligation of DNA strands, leading to DNA breaks and apoptosis. In the tumor microenvironment, where β-glucuronidase is highly expressed, β-Glu-PAB (CH2NH2) -Exatecan is specifically cleaved to release Exatecan, which then exerts its cytotoxic effects. Additionally, β-Glu-PAB (CH2NH2) -Exatecan serves as an intermediate for the synthesis of Mal ((3S,3aR,6S,6aR) -Hexahydrofuro[3,2-b]furan-3,6-diamine-PEG12) -β-Glu-PAB-Exatecan. This compound holds potential for cancer research.

Topoisomerase

DNA Damage/DNA Repair

3025094

C39H39FN4O13

790.74

N(C(OCC1=CC(CN)=C(O[C@@H]2O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]2O)C=C1)=O)[C@@H]3C4=C5C(C=6N(C5)C(=O)C7=C(C6)[C@](CC)(O)C(=O)OC7)=NC=8C4=C(CC3)C(C)=C(F)C8

-20°C

Ice Packs

Small Compound