Glucagon Receptor Antagonist I - CAS 438618-32-7

Glucagon receptor antagonist I is a competitive antagonist of the glucagon receptor (GCGR; IC50 = 181 nM) . It blocks glucagon-induced glycogenolysis in primary human hepatocytes and isolated liver. Glucagon receptor antagonist I, at 50 mg/kg, reduces the increase in glucose levels observed after intraperitoneal administration of glucagon in humanized mice. Glucagon receptor antagonist inactive control does not prevent glucagon-mediated actions.

Others, Glucagon Receptor, AChR

Neuroscience, Others, GPCR/G Protein

438579

C20H30N2OS

346.53

C(#N)C=1C2=C(SC1NC(C(CC)CC)=O)CC(C(CC)(C)C)CC2

-20°C

Ice Packs

Small Compound