Glucocorticoid receptor modulator 1 - CAS 2868357-11-1

Glucocorticoid receptor modulator 1 is a highly effective and orally administered NF-κB and AP-1 inhibitor with IC50 values of 9 nM and 130 nM, respectively. It can downregulate the expression of inflammatory factors IL-6, IL-1β, TNF-α, and MMP-13, thereby alleviating skin inflammation.

TNF, DNA/RNA Synthesis, Glucocorticoid Receptor, MMP, IL Receptor, NF-κB

Cell Cycle/Checkpoint, Apoptosis, Proteases/Proteasome, NF-κB, Endocrinology/Hormones, Immunology/Inflammation, DNA Damage/DNA Repair

2868345

0.9979

C24H23ClN2O4S

470.97

O=C(C=1C=CC=CC1)N2C3=CC=C(C=C3CCC2)NS(=O)(=O)C=4C=C(Cl)C(=CC4OC)C

-20°C

Ice Packs

Small Compound