Glucocorticoid receptor modulator 3 - CAS 2688785-13-7

Glucocorticoid receptor modulator3 (Payload 6) is a thioester-based modulator of the glucocorticoid receptor, exhibiting a potent IC50 value of 0.6 nM. This compound is deactivated through rapid hepatic metabolism, minimizing systemic exposure of its unconjugated active payload. Glucocorticoid receptor modulator3 is suitable for development in antibody-drug conjugates (ADCs) targeted at autoimmune diseases.

Glucocorticoid Receptor

Endocrinology/Hormones

2688785-13-7

C29H32F3NO5S

563.63

O(C(=O)C1=CC(N)=C(F)C=C1)[C@@]2(C(SCF)=O)[C@]3(C)[C@@](C[C@H]2C)([C@]4([C@](F)([C@@H](O)C3)[C@]5(C)C(CC4)=CC(=O)C=C5)[H])[H]

-20°C

Ice Packs

Small Compound