Glucosylceramide synthase-IN-4 - CAS 2776965-41-2

Glucosylceramide Synthase-IN-4 (compound 12) serves as a potent inhibitor of glucosylceramide synthase (GCS), exhibiting an IC50 of 6.8 nM. It demonstrates superior pharmacokinetic properties and robust stability in human hepatocytes. Additionally, this compound is noted for its effective CNS penetration and acceptable PXR selectivity [1].

Transferase

Metabolism

2776965-41-2

C22H18F5N3O3

467.39

O=C1C2=C(C(F)=C(F)C=C2CN1[C@@H](C(C)(C)O)C(F)(F)F)C3=CC=C(C=C3)C=4OC(C)=NN4

-20°C

Ice Packs

Small Compound