GluR23Y - CAS 696659-27-5

GluR23Y, a biologically active peptide, was utilized in an ELISA-based cell-surface assay to assess insulin-stimulated endocytosis of native AMPA receptors in cultured hippocampal neurons. GluR23Y effectively inhibited the insulin-induced decrease in receptor presence. The inhibition of insulin effects was achieved by introducing GluR23Y into neurons through fusion with the membrane transduction domain of HIV-1 TAT.

IGluR

Membrane transporter/Ion channel, Neuroscience

696659-27-5

C51H69N11O16

1092.16

[C@H](CC1=CC=C(O)C=C1)(C(N[C@H](C(N[C@H](C(N[C@@H](CC2=CC=C(O)C=C2)C(NCC(O)=O)=O)=O)[C@H](C)C)=O)CC(N)=O)=O)NC(CNC([C@@H](NC([C@@H](NC([C@H](CC3=CC=C(O)C=C3)N)=O)CCCCN)=O)CCC(O)=O)=O)=O

-20°C

Ice Packs

Peptide