GN44028 - CAS 1421448-26-1

GN44028 (N- (2,3-Dihydro-1,4-benzodioxin-6-yl) -1,4-dihydroindeno[1,2-c]pyrazol-3-amine) is a hypoxia-inducible factor inhibitor of (HIF) -1 (IC50: 14 nM) . GN44028 inhibits hypoxia-induced HIF-1α transcriptional activity. However, It can not be suppressing HIF-1α mRNA expression, HIF-1α protein accumulation, or HIF-1α/HIF-1β heterodimerization.

HIF/HIF Prolyl-Hydroxylase, HIF

Metabolism, Angiogenesis, Chromatin/Epigenetic

1421421

0.9952

C18H15N3O2

305.33

C1c2ccccc2-c2[nH]nc(Nc3ccc4OCCOc4c3)c12

-20°C

Ice Packs

Small Compound