GNE-0439 - CAS 1241902-40-8

GNE-0439 is a novel, Nav1.7-selective inhibitor with an IC50 of 0.34 uM that also inhibits Nav1.5 (IC50=38.3 uM) and mutant N1742K channels (IC50=0.37 uM), possessing a carboxylic acid group that binds outside the channel pore, distinguishing it from known selective VSD4 binders and making it a valuable tool for ion channel research.

Sodium Channel

Membrane transporter/Ion channel

1241854

0.996

C21H31NO3

345.48

C(N[C@@H]([C@@H](C)C)C(O)=O)(=O)C1=CC=C(C=C1)C2CCC(CCC)CC2

-20°C

Ice Packs

Small Compound