GNE-049 - CAS 1936421-41-8

GNE-049 is a highly selective and potent inhibitor designed to target the CREB-binding protein (CBP) with high affinity, exhibiting an IC50 of 1.1 nM for the suppression of BRET and BRD4 activity, which consequently blocks prostate cancer cell proliferation in both in vitro and in vivo models.

Epigenetic Reader Domain, Histone Acetyltransferase

Chromatin/Epigenetic

1936372

0.9867

C27H32F2N6O2

510.58

O=C(N1CC=2C(=NN(C2CC1)C3CCOCC3)N4C=5C=C(C(=CC5CCC4)C=6C=NN(C6)C)C(F)F)C

-20°C

Ice Packs

Small Compound