GNE-064 - CAS 1997321-20-6

GNE-064 is a selective, orally active and highly soluble inhibitor of SMARCA4, SMARCA2 and PBRM1 bromodomains 5. GNE-064 inhibits SMARCA4 with an IC50 of 0.035 μM and inhibits SMARCA2 with an EC50 of 0.10 μM. GNE-064 possess Kds with 0.01, 0.016, 0.018 and 0.049 μM for SMARCA4, SMARCA2, PBRM1 bromodomains 5 and PBRM1 bromodomains 2, repectively. GNE-064 can be used as a chemical probe for the research of drug synthesis.

Epigenetic Reader Domain

Chromatin/Epigenetic

1997295

0.9991

C17H21N5O2

327.38

C[C@@H]1CN(CCN1C(C)=O)c1cc(nnc1N)-c1ccccc1O

-20°C

Ice Packs

Small Compound