Molfinity

GNE-0946 - CAS 1677667-24-1

SKU:MF-0032930

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Size 1 mg

Product Details

Bioactivity
GNE-0946 is an effective and selective RORγ/RORc/NR1F3 antagonist (inverse agonist) with an EC50 of 4 nM in HEK-293 cells. It inhibits IL-17 production in human PBMC cells (IC50 = 17 nM) and can be used in autoimmune disease research.
Target
ROR
Related Pathways
Metabolism
CAS Number
1677642
Molecular Formula
C22H12ClF3N2O4
Molecular Weight
460.79
SMILES
O=C(O)C=1C=CC(=CC1O)C=2N=C(C(=O)C=3C(Cl)=CC=CC3C(F)(F)F)N4C=CC=CC24
Storage Temperature
-20°C
Shipping Conditions
Ice Packs
Category
Small Compound