GNE-274 - CAS 2369048-69-9

GNE-274, a non-degrader compound structurally similar to GDC-0927 (an ER degrader), serves as a partial ER agonist in breast cancer cell lines without triggering ER turnover. Notably, GNE-274 enhances chromatin accessibility at ER-DNA binding sites, unlike GDC-0927. Acting as a potent inhibitor of the ER-ligand binding domain (LBD), GNE-274 exhibits potential for cancer research purposes.

Others, Estrogen Receptor/ERR

Others, Endocrinology/Hormones

2368970

C29H31NO4

457.57

CCCN1CC(COc2ccc(cc2)[C@@H]2Oc3ccc(O)cc3C(C)=C2c2cccc(O)c2)C1

-20°C

Ice Packs

Small Compound