GNE-5152 - CAS 3080315-83-6

GNE-5152 is a straight-chain SARM1 base exchange (BE) inhibitor. Under mild activation conditions, GNE-5152 persistently activates SARM1 at sub-inhibitory concentrations, which synergistically enhances NAD consumption, leading to axonal degeneration and neurodegeneration, and releases neurofilament light chain (NfL) in cortical neurons. GNE-5152 is applicable in neurodegenerative disease research.

TLR

Immunology/Inflammation

3080226

C21H17F2N3O

365.38

O=C1N(C=2C=NC(=CC2)C=3C=CN=CC3)CCC(C4=CC=C(F)C(F)=C4)C1

-20°C

Ice Packs

Small Compound