GNE-5729 - CAS 2026635-66-3

GNE-5729 is a positive allosteric modulator of NMDAR with the advantage of crossing the blood-brain barrier and being orally available, with EC50 values of 37 nM, 4.7 μM and 9.5 μM for GluN2A, GluN2C and GluN2D, respectively, and can be used for the study of neurological and psychiatric disorders.

IGluR, NMDAR

Membrane transporter/Ion channel, Neuroscience

2026566

0.9985

C17H10Cl2F3N5O

428.2

ClC1=C(N2C(=NC(CN3N=C(C(F)(F)F)C=C3Cl)=CC2=O)C=C1)[C@H]4[C@H](C#N)C4

-20°C

Ice Packs

Small Compound