GNF-6 - CAS 839708-29-1

GNF-6 (Compound 14), an ATP competitive inhibitor, inhibits the gatekeeper threonine residue mutation of BCR-ABL-T315I with IC50 values of 0.25 μM for c-ABL-T334I, 0.09 μM for BCR-ABL, and 0.590 μM for BCR-ABL-T315I variants. It disrupts the assembly of the hydrophobic spine (a network of hydrophobic interactions), locking the kinase in an inactive 'DFG-out' conformation [1].

Bcr-Abl

Cytoskeletal Signaling, Tyrosine Kinase/Adaptors, Angiogenesis

839708-29-1

C22H19F3N6O2

456.42

O=C1N(CC=2C(N1C)=NC(N)=NC2)C3=CC(NC(=O)C4=CC(C(F)(F)F)=CC=C4)=CC=C3C

-20°C

Ice Packs

Small Compound