GNF-8625 - CAS 1196546-33-4

GNE-8525 is a potent and selective pan-TRK inhibitor. GNE-8525 demonstrated potent antiproliferation activity with IC50 = 0.003 μM. In a tumor xenograft model derived from the KM12 cell line, GNE-8525 demonstrated in vivo antitumor efficacy when administered at ascending doses twice daily (bid) for 14 days in rats. Deregulated kinase activities of tropomyosin receptor kinase (TRK) family members have been shown to be associated with tumorigenesis and poor prognosis in a variety of cancer types. In particular, several chromosomal rearrangements involving TRKA have been reported in colorectal, papillary thyroid, glioblastoma, melanoma, and lung tissue that are believed to be the key oncogenic driver in these tumors.

Others, Ligands for Target Protein for PROTAC, Trk receptor

PROTAC, Tyrosine Kinase/Adaptors, Others

1196509

C31H30FN7O

535.61

FC=1C=C([C@@H]2N(C3=NN4C(=CN=C4C=C3)C=5N=C(C=CC5)C=6C=C(N=CC6)N7CCC(O)CC7)CCC2)C=CC1

-20°C

Ice Packs

Small Compound