GNF2133 hydrochloride - CAS 2561414-57-9

GNF2133 hydrochloride is a selective, effective, and orally active DYRK1A inhibitor, able to act on DYRK1A (IC50: 0.0062 μM) and GSK3β (IC50> 50 μM) ; GNF2133 hydrochloride showed good proliferative ability and efficacy in rat and human primary β cells. GNF2133 hydrochloride significantly improved glucose processing ability and increased insulin secretion. GNF2133 hydrochloride has the potential to study type 1 diabetes.

DYRK, Others

Tyrosine Kinase/Adaptors, Cell Cycle/Checkpoint, Others

2561348

C24H31ClN6O2

471

Cl.CCN1CCN(CC1)C(=O)Nc1cc(ccn1)-c1cn(C2CCOCC2)c2cnccc12

-20°C

Ice Packs

Small Compound