Gossypetin - CAS 489-35-0

Gossypetin, a hexahydroxylated flavonoid extractable from Rhodiola rosea Linn. is a potent MKK3 and MKK6 inhibitor that strongly attenuates the MKK3/6-p38 signaling pathway.Gossypetin exhibits antimutagenic, antiatherosclerotic, antioxidant, as well as cytoprotective and antimicrobial effects.It inhibits bone resorption by downregulating lysosomal caspase K activity and inducing autophagy-associated proteins in actin ring osteoclasts. Gossypetin has anti-mutagenic, anti-atherosclerotic, anti-oxidant, cytoprotective and antibacterial effects, and it inhibits bone resorption by down-regulating lysosomal caspase K activity and by inducing autophagy-associated protein in actin ring osteoblasts.

MAPK, MEK, p38 MAPK, Antioxidant, Antibacterial

Oxidation-Reduction, Microbiology/Virology, MAPK

454

0.95

C15H10O8

318.24

Oc1ccc(cc1O)-c1oc2c(O)c(O)cc(O)c2c(=O)c1O

-20°C

Ice Packs

Natural Product