GPR183 antagonist-2 - CAS 2924063-98-7

GPR183 antagonist-2 (compound 32), a selective antagonist of GPR183, exhibits excellent water solubility and pharmacokinetic properties. This compound effectively diminishes paw and joint swelling, and reduces gene expression of pro-inflammatory cytokines (MCP-1, MMPs, and VEGF) in a dose-dependent manner within a collagen-induced arthritis (CIA) mouse model. GPR183 antagonist-2 is applicable in researching autoimmune diseases [1].

EBI2/GPR183

GPCR/G Protein

2924063-98-7

C20H18F2N4O5

432.38

C(=C/C(=O)N1CCN(C(=O)C=2C=NC(OC)=NC2)CC1)\C=3C=C4C(=CC3)OC(F)(F)O4

-20°C

Ice Packs

Small Compound