GPX4-IN-13 - CAS 2644044-43-7

GPX4-IN-13 (compound 16), a GPX4 inhibitor, exhibits anticancer properties by diminishing the expression of GPX4, thereby reducing thyroid cell proliferation and inducing ferroptosis. Additionally, this compound effectively inhibits the growth of three distinct thyroid cancer cell lines: N-thy-ori-3-1 (IC 50 =8.39 μM), MDA-T32 (IC 50 =10.28 μM), and MDA-T41 (IC 50 =8.18 μM) .

Glutathione Peroxidase, Ferroptosis

Metabolism, Apoptosis

2643994

C23H15NO3

353.37

O(C1=C(/C=C/C(=O)C2=CC=C(C#N)C=C2)C=CC=C1)C3=C(C=O)C=CC=C3

-20°C

Ice Packs

Small Compound