Groenlandicine - CAS 38691-95-1

Groenlandicine is a protoberberine alkaloid from Coptidis Rhizoma. Groenlandicine exhibits moderate inhibitory effect with IC50 value of 154.2 μM for human recombinant aldose reductase (HRAR) . Groenlandicine selectively induces topoisomerase I-mediated DNA cleavage; Groenlandicine may be a promising anti-Alzheimer's disease agent due to its potent inhibitory activity of both ChEs and beta-amyloids formation, as well as marked ONOO (-) scavenging and good ROS inhibitory capacities.

ROS, Apoptosis, Beta-Secretase, Cholinesterase (ChE), Topoisomerase

Immunology/Inflammation, Apoptosis, DNA Damage/DNA Repair, Neuroscience

38595

0.9977

C19H16NO4

322.34

O(C)C=1C=C2C=3[N+](=CC4=C(C3)C=CC5=C4OCO5)CCC2=CC1O

-20°C

Ice Packs

Natural Product