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Molfinity

GS143 - CAS 916232-21-8

GS143 - CAS 916232-21-8

MF-0017637-01

$33.92 USD
$33.92 USD
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Product Details

  • Bioactivity

    GS143 is a selective IκBα ubiquitination inhibitor with an IC50 of 5.2 μM for SCFβTrCP1-mediated IκBα ubiquitylation. It suppresses NF-κB activation and transcription of target genes without inhibiting proteasome activity. GS143 has anti-asthm[atic] properties.

  • Target

    NF-κB, IκB/IKK, E1/E2/E3 Enzyme

  • Related Pathways

    Ubiquitination, NF-κB

  • CAS Number

    916203

  • Purity

    0.9972

  • Molecular Formula

    C28H19FN2O4

  • Molecular Weight

    466.46

  • SMILES

    OC(=O)c1ccc(cc1)N1N=C(Cc2ccccc2)\C(=C/c2ccc(o2)-c2ccccc2F)C1=O

  • Storage Temperature

    -20°C

  • Shipping Conditions

    Ice Packs

  • Category

    Small Compound