GSK-1482160 - CAS 1001389-72-5

GSK-1482160 is a CNS-penetrant negative allosteric modulator of P2X7 receptor with oral activity. The P2X7 receptor is involved in the production of pro-inflammatory cytokines by central and peripheral immune cells, so GSK-1482160 has the potential to study inflammatory diseases. GSK-1482160 shows excellent in vitro potency (in functional and electrophysiological assays at recombinant and naive P2X7 receptors across multiple species including humans) and cross-target selectivity.

P2X Receptor

Neuroscience, Membrane transporter/Ion channel

1001312

0.9987

C14H14ClF3N2O2

334.72

CN1[C@@H](CCC1=O)C(=O)NCc1cccc(c1Cl)C(F)(F)F

-20°C

Ice Packs

Small Compound