GSK-2250665A - CAS 1246030-96-5

GSK-2250665A is an interleukin-2-inducible T-cell kinase (Itk) inhibitor with a binding affinity of pKi = 9.2, GSK-2250665A demonstrates significant selectivity for Itk over Aurora B kinase and Bruton's tyrosine kinase (Btk), with pIC50 values of 6.4 and 6.5 respectively, while also showing limited activity against other kinases, and GSK-2250665A inhibits interferon-gamma (IFNγ) production in peripheral blood mononuclear cells (PBMCs), establishing it as a highly selective chemical probe for T-cell receptor signaling research and immune modulation studies.

Tyrosine Kinases

Tyrosine Kinase/Adaptors

1245929

0.9938

C26H29N5OS

459.61

N(C=1SC=2C(N1)=CC=C(CC)C2)C3=NC(N[C@H]4CC[C@H](O)CC4)=NC(CC5=CC=CC=C5)=C3

-20°C

Ice Packs

Small Compound