GSK-3α/β-IN-1 - CAS 1574354-24-7

GSK-3α/β-IN-1 is a GSK-3α/β inhibitor with IC50 values of 0.265 μM for GSK-3α and 0.255 μM for GSK-3β. It also inhibits PKA with an IC50 of 0.188 μM. GSK-3α/β-IN-1 effectively reduces cell viability in three glioblastoma (GBM) cell lines (IC50: 3-6 μM over 72 hours) without being toxic to human astrocytes, and it exhibits good metabolic stability. Additionally, it shows potential central nervous system activity in a whole human blood-brain barrier (BBB) GBM model.

GSK-3, PKA

PI3K/Akt/mTOR signaling, Stem Cells, Tyrosine Kinase/Adaptors

1574323

C21H17N3O2

343.38

OC=1C=CC2=C(OC3=C2NC4=NN=CC4=C3C=5C=CC(=CC5)C(C)C)C1

-20°C

Ice Packs

Small Compound