GSK-3β inhibitor 17 - CAS 2521624-67-7

GSK-3β Inhibitor 17 (compound 5 n) reduces the expression of p-p65 and KIM-1 proteins in a dose-dependent manner (16, 32, 64 μM) induced by cisplatin. Additionally, at a concentration of 32 μM, it decreases the levels of TNF-α, IL-1β, IL-6, and MCP-1 mRNA in an acute kidney injury (AKI) model of HK-2 cells triggered by cisplatin.

GSK-3

Stem Cells, PI3K/Akt/mTOR signaling

2521624-67-7

C26H18F3N5O6S2

617.58

O=C(OC)C=1SC(=CC1)S(=O)(=O)NC=2C=CC(=CC2)C3=NC(=NO3)C=4C=CN=C(C4)NC5=CC=C(OC(F)(F)F)C=C5

-20°C

Ice Packs

Small Compound