GSK-3 inhibitor 3 - CAS 2227279-84-5

GSK-3 inhibitor 3 is a selective, orally active, brain-permeable GSK-3 inhibitor that inhibits GSK-3α and GSK-3β with IC50s of 0.35 nM and 0.25 nM, respectively.GSK-3 inhibitor 3 reduces the phosphorylation level of tau protein S396 with an IC50 of 10 nM in a triple transgenic mouse model of Alzheimer's disease. GSK-3 inhibitor 3 reduced the phosphorylation level of tau protein S396 in a triple transgenic mouse model of Alzheimer's disease, with an IC50 of 10 nM.GSK-3 inhibitor 3 can be used for the study of neurological diseases.

Microtubule Associated, GSK-3

Stem Cells, PI3K/Akt/mTOR signaling, Cytoskeletal Signaling

2227190

0.9989

C23H15FN6O

410.4

N(C(=O)C1=NC(NC2=CC=C(C#N)C=C2)=NC=C1)C=3C(=CC=NC3)C4=CC=C(F)C=C4

-20°C

Ice Packs

Small Compound