GSK-3 inhibitor 4 - CAS 2227279-83-4

GSK-3 inhibitor 4 is an orally active and brain-permeable compound that acts as a triple inhibitor of GSK-3, CDK2, and CDK5, with IC50 values of 0.56 nM (GSK-3β), 0.45 nM (GSK-3α), 0.47 μM (CDK2), and 0.68 μM (CDK5) . It effectively reduces Tau protein levels and can be used in the study of Alzheimer's disease.

GSK-3, CDK

Stem Cells, Cell Cycle/Checkpoint, PI3K/Akt/mTOR signaling

2227192

0.9982

C22H15F2N5O

403.38

N(C(=O)C1=NC(NC2=CC=C(F)C=C2)=NC=C1)C=3C(=CC=NC3)C4=CC=C(F)C=C4

-20°C

Ice Packs

Small Compound