GSK-7227 - CAS 1067214-81-6

GSK-7227, a novel compound representing a novel class of peroxisome proliferator-activated receptor delta (PPARδ) partial agonists, demonstrates potent partial agonistic activity by upregulating the expression of PPARδ target genes, specifically carnitine palmitoyltransferase 1a (CPT1a) and pyruvate dehydrogenase kinase 4 (PDK4), in cultured skeletal muscle cells, indicating its potential role in modulating skeletal muscle metabolism and energy homeostasis.

Dehydrogenase, PPAR, PDK, CPT

DNA Damage/DNA Repair, PI3K/Akt/mTOR signaling, Metabolism

1067127

0.9917

C25H22N2O6S

478.52

O=C(O)C1=CC(=CC=C1NC(=O)C2=CC=CC(=C2)S(=O)(=O)N3C=CC=4C3=CC=C(OC)C4C)C

-20°C

Ice Packs

Small Compound