GSK143 - CAS 1240390-27-5

GSK143 is a potent orally active and highly selective inhibitor of spleen tyrosine kinase (SYK) with a pIC 50 of 7.5. Furthermore, GSK143 effectively inhibits phosphorylated Erk (pErk) with a pIC 50 value of 7.1. In addition, GSK143 exhibits promising anti-inflammatory properties by reducing inflammation and impeding the recruitment of immune cells in the intestinal muscularis of mice.

Others, ERK, Syk

MAPK, Others, Angiogenesis, Tyrosine Kinase/Adaptors

1240358

C17H22N6O2

342.403

Cc1ccc(Nc2nc(N[C@@H]3CCOC[C@@H]3N)ncc2C(N)=O)cc1

-20°C

Ice Packs

Small Compound