GSK163929 - CAS 716354-04-0

GSK163929 (compound 122) is an orally active CCR5 antagonist with anti-HIV properties and demonstrates low inhibitory potency against hEGR. Administered at a dosage of 2000 mg/kg/day (i.v., 7 d), it shows no adverse effects in rats, and at 250 mg/kg/day (i.v., 7 d), it is similarly non-toxic in dogs.

HIV Protease, CCR

Microbiology/Virology, GPCR/G Protein, Immunology/Inflammation, Proteases/Proteasome

716354-04-0

C36H40ClF2N5O3S

696.25

C(CN1[C@@]2(C[C@H](C[C@]1(CC2)[H])N3C=4C(N=C3C)=CC=CC4)[H])C5(CCN(C(=O)C6=CC(S(NC)(=O)=O)=C(F)C=C6Cl)CC5)C7=CC(F)=CC=C7

-20°C

Ice Packs

Small Compound