GSK1842799 HCl - CAS 1277165-15-7

GSK1842799 is a selective S1P1 receptor agonist for multiple sclerosis. Upon phosphorylation, GSK1842799 showed subnanomole S1P1 agonist activity with >1000x selectivity over S1P3. GSK1842799 demonstrated good oral bioavailability. On the basis of the favorable in vitro ADME and in vivo PK/PD properties as well as broad toxicology evaluations, GSK1842799 was selected as a candidate for further clinical.

Others, Endogenous Metabolite

Metabolism, Others

1277143

C20H30Cl2F3N3O2S

504.4342

Cl.Cl.CCCCCCCCOc1ccc(cc1C(F)(F)F)-c1nnc(s1)[C@@](C)(N)CO

-20°C

Ice Packs

Small Compound