GSK2220691 - CAS 1206619-37-5

SK2220691 is a potent TRPV4 inhibitor. It effectively suppresses pulmonary edema induced by GSK1016790. Additionally, SK2220691 inhibits the increase of crucial factors such as VEGF, keratinocyte-derived chemokine (KC; CXCL1), and granulocyte colony-stimulating factor (GCSF) induced by hydrochloric acid.

TRP/TRPV Channel

Membrane transporter/Ion channel

1206577

C32H33N5O3

535.64

C([C@@H](NC(=O)C1=CC=2C(N1)=CC=CC2)[C@@](C)(C)C)(=O)N3[C@@]4(CN(C(=O)C5=CC=C(C=N5)C6=CC=CC=C6)[C@@](C4)(C3)[H])[H]

-20°C

Ice Packs

Small Compound