GSK2646264 - CAS 1398695-47-0

GSK2646264 (Compound 44) is a highly effective and specific inhibitor of spleen tyrosine kinase (SYK) with a pIC50 of 7.1. It also inhibits multiple kinases, including LCK (pIC50 5.4), LRRK2 (pIC50 5.4), GSK3β (pIC50 5.3), JAK2 (pIC50 5), VEGFR2 (pIC50 4.5), Aurora B (pIC50 <4.6), and Aurora A (pIC50 <4.3) . Notably, GSK2646264 demonstrates skin penetrability, reaching both the epidermis and dermis [1].

Others, VEGFR, GSK-3, JAK, LRRK2, Aurora Kinase, Syk, Src

Autophagy, Cell Cycle/Checkpoint, Tyrosine Kinase/Adaptors, Chromatin/Epigenetic, Stem Cells, Others, PI3K/Akt/mTOR signaling, Angiogenesis, JAK/STAT signaling

1398648

C24H26N2O2

374.48

COc1cccc(OCc2cc(C)ccn2)c1-c1ccc2CCNCCc2c1

-20°C

Ice Packs

Small Compound