GSK3β-IN-2 - CAS 3068378-38-8

GSK3β-IN-2 (Compound S01) is an inhibitor of GSK3β with an IC50 of 0.35 nM. It activates the Wnt/β-catenin signaling pathway, promoting neurogenesis and neurite outgrowth. GSK3β-IN-2 reduces tau protein phosphorylation induced by Aβ at the Ser396 site, thereby decreasing neurofibrillary tangles. Furthermore, GSK3β-IN-2 improves Alzheimer's disease symptoms in a zebrafish model.

Wnt/beta-catenin, GSK-3

Cytoskeletal Signaling, Stem Cells, PI3K/Akt/mTOR signaling

3068332

C25H18N4O

390.437

O=C(NC=1C=NC=CC1C=2C=CC=CC2)C3=CNC4=NC=C(C=C43)C=5C=CC=CC5

-20°C

Ice Packs

Small Compound