GSK3β-IN-3 - CAS 301359-45-5

GSK3β-IN-3 is an ATP-competitive GSK-3β inhibitor (IC50= 0.90 μM) that demonstrates good blood-brain barrier permeability (Pe= 10.7 x 10^-6 cm/s) . It effectively reduces tau protein phosphorylation in the BR5706 strain and decreases Aβ aggregate deposition in the CL2006 strain, indicating its potential as a candidate for Alzheimer's disease (AD) research.

GSK-3, Cytochromes P450

PI3K/Akt/mTOR signaling, Stem Cells, Metabolism

301309

C14H15ClN2O2S

310.8

O=C(OCC)C1=C(NC(=S)NC1C=2C=CC=CC2Cl)C

-20°C

Ice Packs

Small Compound