GSK321 - CAS 1816331-63-1

GSK321 is a selective and potent mutant isocitrate dehydrogenase 1 (IDH1) inhibitor that inhibits lipid synthesis and blocks cell proliferation in OPA1-deficient MEFs and prevents cytoplasmic glutamine reductive carboxylation.GSK321 has been used in the study of leukemia.

Dehydrogenase, Isocitrate Dehydrogenase (IDH)

Metabolism

1816267

0.9973

C28H28FN5O3

501.55

C(N1C2=C(C(C(NC3=CC([C@H](C)O)=CC=C3)=O)=N1)CN(C(=O)C4=CC=CN4)C[C@H]2C)C5=CC=C(F)C=C5

-20°C

Ice Packs

Small Compound