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Molfinity

GSK3494245 - CAS 2080410-41-7

GSK3494245 - CAS 2080410-41-7

MF-0043339-01

$1,524.20 USD
$1,524.20 USD
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Product Details

  • Bioactivity

    GSK3494245 (DDD01305143) is a potent, selective, orally active inhibitor of chymotrypsin-like activity that binds to the proteasome of WTL.donovani (IC50: 0.16 μM), sandwiched between the β4 and β5 subunits, exhibiting good biosafety properties and suitability for inhibiting chymotrypsin-like activity of the human proteasome (IC50: 26S=13 μM; enriched THP-1 extract IC50=40 μM) .

  • Target

    Parasite, Proteasome, Others

  • Related Pathways

    Ubiquitination, Microbiology/Virology, Others, Proteases/Proteasome

  • CAS Number

    2080362

  • Purity

    0.9585

  • Molecular Formula

    C21H23FN6O2

  • Molecular Weight

    410.44

  • SMILES

    Fc1ccc(NC(=O)N2CCCC2)cc1-c1ccn2c(cnc2n1)N1CCOCC1

  • Storage Temperature

    -20°C

  • Shipping Conditions

    Ice Packs

  • Category

    Small Compound