GSK4418959 - CAS 3064599-36-3

GSK4418959 (IDE275) is a non-covalent, reversible, selective, and orally active inhibitor of the Werner syndrome helicase (WRN helicase) . GSK4418959 inhibits both ATPase and DNA unwinding activities of WRN helicase in an ATP-competitive manner. GSK4418959 is a valuable chemical tool for the study of microsatellite instability-high (MSI-H) cancers, where WRN helicase plays an essential role in maintaining genomic stability.

DNA/RNA Synthesis

DNA Damage/DNA Repair, Cell Cycle/Checkpoint

3064560

0.99141

C31H30F4N4O5S

646.65

C(O)(=O)[C@@H]1[C@H](CCC[C@H]1C(NC2=C(F)C=C(C(F)(F)F)C=C2)=O)C3=CC=C(N(S(=O)(=O)C=4C=C5C(=CC4)N(C)C(C)=N5)C)C=C3

-20°C

Ice Packs

Small Compound