GSK4418959 (enantiomer) - CAS 3064599-37-4

GSK4418959 enantiomer is the enantiomer of GSK4418959. GSK4418959 (IDE275) is a non-covalent, reversible, selective helicase inhibitor of WRN with oral bioavailability. It competitively inhibits ATPase and DNA unwinding functions in an ATP-dependent manner. GSK4418959 is utilized in the study of microsatellite instability-high (MSI-H) cancer.

DNA/RNA Synthesis

Cell Cycle/Checkpoint, DNA Damage/DNA Repair

3064599-37-4

C31H30F4N4O5S

646.65

C(O)(=O)[C@H]1[C@@H](CCC[C@@H]1C(NC2=C(F)C=C(C(F)(F)F)C=C2)=O)C3=CC=C(N(S(=O)(=O)C=4C=C5C(=CC4)N(C)C(C)=N5)C)C=C3

-20°C

Ice Packs

Inhibitors & Agonists