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GSK484 hydrochloride - CAS 1652591-81-5

GSK484 hydrochloride - CAS 1652591-81-5

MF-0019969-01

$58.59 USD
$58.59 USD
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Product Details

  • Bioactivity

    GSK484 hydrochloride (GTPL8577) is a reversible peptidyl-arginine deiminase 4 (PAD4) inhibitor. It binds to PAD4 with high affinity, with IC50 of 250 and 50 nM in the presence and absence of 2 mM calcium, respectively. GSK484 promotes the radiosensitivity of colorectal cancer (CRC) and inhibits NET formation in vitro and in vivo.

  • Target

    PAD

  • Related Pathways

    Chromatin/Epigenetic

  • CAS Number

    1652505

  • Purity

    0.9962

  • Molecular Formula

    C27H32ClN5O3

  • Molecular Weight

    510.03

  • SMILES

    Cl.COc1cc(cc2nc(-c3cc4ccccc4n3CC3CC3)n(C)c12)C(=O)N1CC[C@@H](O)[C@@H](N)C1

  • Storage Temperature

    -20°C

  • Shipping Conditions

    Ice Packs

  • Category

    Small Compound