GSK778 - CAS 2451862-42-1

GSK778 is a potent and selective inhibitor of BD1 bromodomain such as BRD2 BD1 (IC50s = 75 nM), BRD3 BD1 (IC50s = 41 nM), BRD4 BD1 (IC50s = 41 nM), and BRDT BD1 (IC50s = 143 nM) . GSK778 inhibits proliferation, induces a cell cycle arrest and apoptosis.

Epigenetic Reader Domain, Apoptosis

Apoptosis, Chromatin/Epigenetic

2451862-42-1

0.9842

C30H33N5O3

511.61

COCc1nc2cnc3cc(-c4c(C)noc4C)c(OC[C@H]4CCNC4)cc3c2n1[C@H](C)c1ccccc1

-20°C

Ice Packs

Small Compound