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GSK778 hydrochloride - CAS 2863657-79-6

GSK778 hydrochloride - CAS 2863657-79-6

MF-0012378-01

$120.06 USD
$76.05 USD $120.06 USD
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Product Details

  • Bioactivity

    GSK778 hydrochloride hydrochloride is a potent and selective BD1 bromodomain inhibitor of the BET proteins, with IC50s of 75 nM (BRD2 BD1), 41 nM (BRD3 BD1), 41 nM (BRD4 BD1), and 143 nM (BRDT BD1), respectively. GSK778 hydrochloride hydrochloride phenocopies the effects of pan-BET inhibitors in cancer models[1].

  • Target

    Apoptosis, Epigenetic Reader Domain

  • Related Pathways

    Apoptosis, Chromatin/Epigenetic

  • CAS Number

    2863657-79-6

  • Purity

    0.9835

  • Molecular Formula

    C30H34ClN5O3

  • Molecular Weight

    548.08

  • SMILES

    C[C@@H](N1C(COC)=NC2=C1C3=CC(OC[C@@H]4CNCC4)=C(C5=C(C)ON=C5C)C=C3N=C2)C6=CC=CC=C6.[H]Cl

  • Storage Temperature

    -20°C

  • Shipping Conditions

    Ice Packs

  • Category

    Small Compound