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Molfinity

GSK8814 - CAS 1997369-78-4

GSK8814 - CAS 1997369-78-4

MF-0032955-01

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Product Details

  • Bioactivity

    GSK8814 is a selective and ATAD2/2B bromodomain chemical probe and inhibitor (binding constant pKd=8.1 and a pKi=8.9 in BROMOscan) . GSK8814 displays 500-fold selectivity for ATAD2 over BRD4 BD1. GSK8814 binds to ATAD2 and BRD4 BD1 (pIC50s: 7.3 and 4.6) .

  • Target

    Epigenetic Reader Domain

  • Related Pathways

    Chromatin/Epigenetic

  • CAS Number

    1997287

  • Molecular Formula

    C28H35F2N5O3

  • Molecular Weight

    527.61

  • SMILES

    CO[C@H]1CNC[C@@H](OCC2CCC(F)(F)CC2)[C@@H]1Nc1ncc(-c2cncc(C)c2)c2cc(C)c(=O)[nH]c12

  • Storage Temperature

    -20°C

  • Shipping Conditions

    Ice Packs

  • Category

    Small Compound