GSK_WRN3 - CAS 2923009-50-9

GSK_WRN3 acts as a selective inhibitor of the WRN protease with an IC 50 of 8.6 μM. It demonstrates significant selectivity by covalently binding to the Cys727 residue of the WRN protein. By inhibiting WRN protease activity, GSK_WRN3 hinders the growth of MSI tumor cells by increasing DNA double-strand breaks and inhibiting cell proliferation [1].

Others, DNA/RNA Synthesis

Others, Cell Cycle/Checkpoint, DNA Damage/DNA Repair

2923009-50-9

C16H20N2O5S

352.4

OC1=C(NC(=O)C(C(N[C@@H]2C=CS(=O)(=O)C2)=O)=C1)C3CCCCC3

-20°C

Ice Packs

Small Compound