GT-02216 - CAS 2648407-76-3

GT-02216 is capable of binding allosterically to GCase, thereby enhancing its function. In primary human fibroblasts, it increases GCase activity and decreases Tau accumulation in mutant GBA1 fibroblasts. Additionally, GT-02216 offers protection to hippocampal primary neurons exposed to Tau oligomer in a rat model.

Glycosidase

Metabolism

2648328

C22H23N5O2

389.45

O=C(C1=NC(N)=CC(=C1)NC=2C=CC=CC2O)N3CCN(C=4C=CC=CC4)CC3

-20°C

Ice Packs

Small Compound